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Consolidating p47

It should be noted that there have been prior hints of prolonged WM consolidation in the schizophrenia literature.Some studies have equated baseline WM performance in schizophrenia patients and healthy controls by increasing exposure time, allowing more time for consolidation, and these studies have found that patients require far longer than controls to reach criterion levels of performance (Hartman, Steketee, Silva, Lanning, & Mc Cann, 2003; Tek et al., 2002).However, the impact of noisy representations on performance may be amplified as memory load increases.Finally, the effects of inaccurate or noisy WM encoding would be expected to influence performance regardless of the nature of the responses required by the task (assuming that the task is sufficiently sensitive).

Studies using attentional blink paradigms have demonstrated that patients require longer intervals between two target stimuli in order to accurately report the occurrence of the second target, suggestive of prolonged encoding times for the first target stimulus (Cheung, Chen, Chen, Woo, & Yee, 2002; Li et al., 2002; Wynn, Breitmeyer, Nuechterlein, & Green, 2006).An array of pattern masks was inserted into the delay interval--covering the locations of the sample-array squares--100-800 ms after the offset of the sample array.If a durable WM representation is formed prior to mask onset, the mask should not impair performance.These data demonstrate abnormally prolonged WM consolidation in schizophrenia.This impairment may slow the formation of stable representations of the visual environment, impacting everyday visually guided behavior.

The degree of masking at an interval reflects the degree of WM consolidation at that time. Unlike controls, patients demonstrated robust masking effects at set size 2.

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Consolidating p47 introduction

Consolidating p47

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